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KMID : 1145120170150020242
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Asian Journal of Beauty and Cosmetology
2017 Volume.15 No. 2 p.242 ~ p.246
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Wnt Signaling in Hair Follicle Development
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Lee Jae-Ho
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Abstract
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Hair follicle (HF) is a miniature organ composed of epithelial and mesenchymal (dermal) compartments, and has a pivotal role in hair development and growth. In embryonic, the formation of HF is mainly regulated by mesenchymal-epithelial interactions within the dermal papilla (DP) niche, and this interaction is also responsible for the postnatal hair growth cycle and regeneration. DP cells are the main components of the mesenchymal compartments in hair bulb, and have an instruction role by generating several signals to regulate the behavior of neighbor epithelial cells in hair cycle. Among the many signaling pathways implicated in HF development and growth, Wnt/β-catenin signaling in DP cells plays critical roles in the reciprocal instructive communication between DP and epithelial cells. It is clear that Wnt/β-catenin signaling pathway is important for HF morphogenesis and regeneration. The goal of this review is to summarize our current knowledge of Wnt signaling pathway in HF development and cycling.
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KEYWORD
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Hair follicle, Dermal papilla cell, Wnt/β-catenin signaling, Growth, Development
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